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KMID : 0648420060110010028
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Journal of Korean Society of Pediatric Endocrinology
2006 Volume.11 No. 1 p.28 ~ p.32
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The Relationship between Insulin-like Growth Factor Binding Protein-3 Promoter Polymorphism and Growth
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Choi Woo-Jin
Yang Seung
Im Jee-Hye
Lee Young-Ik
Shin Jeh-Hoon
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Abstract
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Purpose: The variability in insulin-like growth factor binding protein-3 (IGFBP-3) levels is related to polymorphic variants of the promoter region of the gene. The most common single nucleotide polymorphism of IGFBP promoter region is -202 locus. In vitro, significantly higher promoter activity of the A allele at the -202 locus compared with the C allele, consistent with the relationship observed between genotype and circulating IGFBP-3 was documented. The polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, but the effects of IGFBP-3 promoter polymorphism on growth in children are unknown.
Methods: RFLP genotyping of the -202 single nucleotide polymorphism was performed in 33 Korean children who visited our clinic for evaluation of their growth. The serum levels of IGF-I and IGFBP-3 were compared according to genotyping.
Results: Height SDS of subjects was -1.48+/-1.10. 11 of 33 children (33%) were heterozygous AC and the others are homozygous AA in genetic distribution, but no homozygous CC was detected. C allele frequency was 16.7%. There were no significant differences in height, body mass index, serum IGF-I and IGFBP-3 levels between AC and AA groups.
Conclusion: The effects of IGFBP-3 promoter polymorphism on growth at the -202 locus deserve investigation because there is no CC and the children were relatively short in this study.
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KEYWORD
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IGFBP-3, Promoter, Polymorphism, Growth
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